One of the core benefits of an electrospun polymeric (ESP) materials is that it structurally mimics the natural biological scaffold onto which native human tissue grows, called extracellular matrix.  This similarity to extracellular matrix encourages natural healing and tissue integration, even when using strong and biodurable electrospun polymers.  This quality of healing is not achieved with woven and knitted biomaterials, which are the current industry standard.  The images below illustrate the stark difference between the microstructure of (a) current woven textile device and (b) naturally-occurring extracellular matrix and (c) our ESP materials.  
 

Current Woven Textile Material

Natural Extracellular Matrix

ESP Material

Fiber Size Matters

 

Evaluation of our ESP materials, which were formed into artificial arteries, using specific staining techniques (histology) shows tissue integration and capillary formation after implantation, while the body walls off woven and knitted materials with a capsule of dense scar tissue.  In the histology image of the industry standard below on the left, the empty spaces between the woven polyester fibers (white circles) and the stained tissue shows poor tissue integration.  The yellow arrow shows the thickness of a blood clot which formed on the blood-contacting surface of the implanted woven artificial artery.  In stark contrast, the image of our ESP artificial artery on the right shows new small arteries (capillaries) formed and complete tissue integration of the ESP material, such that the fibers are hardly discernable from the tissue.  The green arrows point out a single layer of cells that has formed on the blood-contacting surface of the artificial artery, and the absence of a clot.  The healing response to the structure of an electrospun material is a vast improvement over current implantable materials. 

Woven Polyester Artificial Artery Histology

Visible separation of tissue from woven fibers (yellow circles)

and thick clot formation (yellow arrows)

ESP Artificial Artery Histology

Capillary formation and excellent tissue integration throughout the material with single cell layer (green arrows) on blood-contacting surface, no visible clot

BioSurfaces, Inc.   •  200 Homer Avenue, Unit 1P  •  Ashland, MA 01721

Telephone: (508) 881-8860  •  Fax: (508) 881-1306  •  Email: info@biosurfaces.us

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