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In Vitro Research Tools (IVRT)
Human‑Relevant Data. No Animal‑Derived Components.
Bio‑Spun® scaffolds are engineered to replicate the body’s natural extracellular matrix (ECM), eliminating the need for animal‑derived materials commonly used in 2D and 3D cell culture. The result is a fully human‑relevant, animal‑free platform that delivers superior reproducibility, consistency, and translational confidence for in vitro research.
Designed for flexibility and performance, Bio‑Spun® scaffolds support advanced tissue development across multiple organ systems while integrating seamlessly with modern in vitro technologies.
Custom Scaffold Solutions
BioSurfaces offers fully customizable Bio‑Spun® scaffold solutions to meet the specific needs of your model system. Our scaffolds can be integrated into a wide range of platforms, including:
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3D bioprinting systems
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Organ‑on‑chip devices
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Cell and gene therapy manufacturing
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Advanced permeability and barrier models
Using our proprietary fabrication process, drugs, growth factors, and other bioactive agents can be incorporated directly into the scaffold, enabling localized delivery, sustained exposure, and precise control of cellular responses.
Tissue Models Developed by BioSurfaces Using Bio-Spun® Scaffolds
Full Thickness Airway Model
H&E-stained cross section of full-thickness human bronchial epithelial model produced on Bio-Spun® PET Scaffold. The scaffold is populated with pulmonary fibroblasts which produce a fully human derived subepithelial matrix component. The fully developed pseudostratified mucociliary epithelium contains basal, goblet and ciliated cells with functional tight junctions.
Full Thickness Skin Model
H&E-stained cross section of full thickness human skin model produced on Bio-Spun® PET Scaffold. Extracellular matrix proteins produced by keratinocytes and fibroblasts self-assemble to form a robust dermal component and basement membrane structures. The epidermis contains a uniform basal keratinocyte layer, granular cell layer, and stratum corneum layer with in vivo-like barrier function.
Customer Developed and Tested Tissue Models Using Bio-Spun® Scaffolds
Retinal Model
H&E-stained cross section of engineered 3D outer blood retinal barrier (3D-oBRB) using Bio-Spun® PDLGA. The scaffold is used to support the development of the 3D-oBRB. By 6 weeks, the tissue has reached maturity with RPE pigmentation (RPE), capillaries (cl) and Bruch's membrane (BM) formation.
Intestinal Model
H&E-stained cross section of human Intestinal epithelial model produced on Bio-Spun® PU Scaffold. The stratified differentiated intestinal epithelium contains villi- and crypt-like structures, contains enterocytes, goblet cells, and Paneth cells and develops functional tight junctions.
Build More Predictive In Vitro Models
Experience the Difference in Your Next Experiment.
Bio‑Spun® scaffolds enable researchers and developers to move beyond animal‑derived matrices - creating more predictive, reproducible, and human‑relevant tissue models.
Let BioSurfaces help you select or design a scaffold solution tailored to your biology, platform, and application.