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One of the core benefits of an electrospun polymeric (Bio-Spun) materials is that it structurally mimics the natural biological scaffold onto which native human tissue grows, called extracellular matrix.  This similarity to extracellular matrix encourages natural healing and tissue integration, even when using strong and biodurable electrospun polymers.  This quality of healing is not achieved with woven and knitted biomaterials, which are the current industry standard.  The images below illustrate the stark difference between the microstructure of (a) current woven textile device and (b) naturally-occurring extracellular matrix and (c) our Bio-Spun materials.  

Standard Woven Textile Material

Natural Extracellular Matrix

Bio-Spun™ Material

Fiber Size Matters


Evaluation of our Bio-Spun™ materials in benchtop or in preclinical studies shows tissue integration.  Upon implantation, capillary formation also occurs.


Biologic Scaffold (Gold Standard) Versus Bio-Spun Synthetic Scaffold 


Biologic proteins such as collagen are typically used to grow tissues from the body such as skin as shown here.  The goal of this type of process is to form a simulated skin layer to use to evaluate disease or as a screening tool for drugs.  For this study, human skin cells seeded on standard (collagen) or Bio-Spun™ scaffolds.  Keratinocytes (pink) and fibroblasts (purple) seeded onto both scaffolds grew similarly on both scaffolds, demonstrating that a synthetic material can be used as a substitute for biologic materials

Cell Chamber Implants.png

Theracyte Cell Chamber (Current Standard) Versus Bio-Spun Cell Chamber  


Cell chambers are being developed to be able to bring a target cell into the body.  This cell can either be genetically-modified to deliver a drug or as is to provide a biologic agent (i.e. islet cell that provides insulin).  Current gold standard Theracyte has limited efficacy due to body's limited healing of the device.  In preclinical studies, healing and drug delivery from the Bio-Spun™ cell chamber was vastly superior to the Theracyte device.  Cell healing of the Bio-Spun™ device, as indicated by purple dots, at 30 days was grossly greater than the Theracyte device, with both devices effectively protecting the loaded cells.   

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